Pesquisa | BVS IEC

1.

APOE3ch alters microglial response and suppresses Aß-induced tau seeding and spread.

Chen, Yun; Song, Sihui; Parhizkar, Samira; Lord, Jennifer; Zhu, Yiyang; Strickland, Michael R; Wang, Chanung; Park, Jiyu; Tabor, G Travis; Jiang, Hong; Li, Kevin; Davis, Albert A; Yuede, Carla M; Colonna, Marco; Ulrich, Jason D; Holtzman, David M.

Cell ; 187(2): 428-445.e20, 2024 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-38086389

2.

The AD odyssey 2023: Tales of single cell.

Luo, Wenjie; Qu, Wenhui; Gan, Li.

Cell ; 186(20): 4257-4259, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774675

3.

Alzheimer's disease: From immunotherapy to immunoprevention.

Jucker, Mathias; Walker, Lary C.

Cell ; 186(20): 4260-4270, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37729908

4.

Human microglial state dynamics in Alzheimer's disease progression.

Sun, Na; Victor, Matheus B; Park, Yongjin P; Xiong, Xushen; Scannail, Aine Ni; Leary, Noelle; Prosper, Shaniah; Viswanathan, Soujanya; Luna, Xochitl; Boix, Carles A; James, Benjamin T; Tanigawa, Yosuke; Galani, Kyriaki; Mathys, Hansruedi; Jiang, Xueqiao; Ng, Ayesha P; Bennett, David A; Tsai, Li-Huei; Kellis, Manolis.

Cell ; 186(20): 4386-4403.e29, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774678

5.

Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion.

Xiong, Xushen; James, Benjamin T; Boix, Carles A; Park, Yongjin P; Galani, Kyriaki; Victor, Matheus B; Sun, Na; Hou, Lei; Ho, Li-Lun; Mantero, Julio; Scannail, Aine Ni; Dileep, Vishnu; Dong, Weixiu; Mathys, Hansruedi; Bennett, David A; Tsai, Li-Huei; Kellis, Manolis.

Cell ; 186(20): 4422-4437.e21, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774680

6.

Accelerating Alzheimer's therapeutic development: The past and future of clinical trials.

Boxer, Adam L; Sperling, Reisa.

Cell ; 186(22): 4757-4772, 2023 10 26.

Artigo em Inglês | MEDLINE | ID: mdl-37848035

7.

Extending genetic risk for Alzheimer's disease from host to holobiont.

Kazmi, Sabeen A; Hsiao, Elaine Y.

Cell ; 186(4): 690-692, 2023 02 16.

Artigo em Inglês | MEDLINE | ID: mdl-36750093

8.

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology.

Mathys, Hansruedi; Peng, Zhuyu; Boix, Carles A; Victor, Matheus B; Leary, Noelle; Babu, Sudhagar; Abdelhady, Ghada; Jiang, Xueqiao; Ng, Ayesha P; Ghafari, Kimia; Kunisky, Alexander K; Mantero, Julio; Galani, Kyriaki; Lohia, Vanshika N; Fortier, Gabrielle E; Lotfi, Yasmine; Ivey, Jason; Brown, Hannah P; Patel, Pratham R; Chakraborty, Nehal; Beaudway, Jacob I; Imhoff, Elizabeth J; Keeler, Cameron F; McChesney, Maren M; Patel, Haishal H; Patel, Sahil P; Thai, Megan T; Bennett, David A; Kellis, Manolis; Tsai, Li-Huei.

Cell ; 186(20): 4365-4385.e27, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774677

9.

Early Alzheimer's disease pathology in human cortex involves transient cell states.

Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, S J; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli-Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna-Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z.

Cell ; 186(20): 4438-4453.e23, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774681

10.

Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration.

Dileep, Vishnu; Boix, Carles A; Mathys, Hansruedi; Marco, Asaf; Welch, Gwyneth M; Meharena, Hiruy S; Loon, Anjanet; Jeloka, Ritika; Peng, Zhuyu; Bennett, David A; Kellis, Manolis; Tsai, Li-Huei.

Cell ; 186(20): 4404-4421.e20, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774679

11.

Lipoproteins in the Central Nervous System: From Biology to Pathobiology.

Raulin, Ana-Caroline; Martens, Yuka A; Bu, Guojun.

Annu Rev Biochem ; 91: 731-759, 2022 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-35303786

12.

APOE told me put my fat in the bag and nobody gets hurt.

Kim, Garam; Gitler, Aaron D.

Cell ; 185(13): 2201-2203, 2022 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-35750028

13.

DUB'ling down uncovers an X-linked vulnerability in Alzheimer's disease.

Paul, Bindu D.

Cell ; 185(21): 3854-3856, 2022 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-36240738

14.

SYK coordinates neuroprotective microglial responses in neurodegenerative disease.

Ennerfelt, Hannah; Frost, Elizabeth L; Shapiro, Daniel A; Holliday, Coco; Zengeler, Kristine E; Voithofer, Gabrielle; Bolte, Ashley C; Lammert, Catherine R; Kulas, Joshua A; Ulland, Tyler K; Lukens, John R.

Cell ; 185(22): 4135-4152.e22, 2022 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-36257314

15.

Spatial proteomics in three-dimensional intact specimens.

Bhatia, Harsharan Singh; Brunner, Andreas-David; Öztürk, Furkan; Kapoor, Saketh; Rong, Zhouyi; Mai, Hongcheng; Thielert, Marvin; Ali, Mayar; Al-Maskari, Rami; Paetzold, Johannes Christian; Kofler, Florian; Todorov, Mihail Ivilinov; Molbay, Muge; Kolabas, Zeynep Ilgin; Negwer, Moritz; Hoeher, Luciano; Steinke, Hanno; Dima, Alina; Gupta, Basavdatta; Kaltenecker, Doris; Caliskan, Özüm Sehnaz; Brandt, Daniel; Krahmer, Natalie; Müller, Stephan; Lichtenthaler, Stefan Frieder; Hellal, Farida; Bechmann, Ingo; Menze, Bjoern; Theis, Fabian; Mann, Matthias; Ertürk, Ali.

Cell ; 185(26): 5040-5058.e19, 2022 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-36563667

16.

X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.

Yan, Yan; Wang, Xinming; Chaput, Dale; Shin, Min-Kyoo; Koh, Yeojung; Gan, Li; Pieper, Andrew A; Woo, Jung-A A; Kang, David E.

Cell ; 185(21): 3913-3930.e19, 2022 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-36198316

17.

Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment.

Piehl, Natalie; van Olst, Lynn; Ramakrishnan, Abhirami; Teregulova, Victoria; Simonton, Brooke; Zhang, Ziyang; Tapp, Emma; Channappa, Divya; Oh, Hamilton; Losada, Patricia M; Rutledge, Jarod; Trelle, Alexandra N; Mormino, Elizabeth C; Elahi, Fanny; Galasko, Douglas R; Henderson, Victor W; Wagner, Anthony D; Wyss-Coray, Tony; Gate, David.

Cell ; 185(26): 5028-5039.e13, 2022 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-36516855

18.

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.

Tcw, Julia; Qian, Lu; Pipalia, Nina H; Chao, Michael J; Liang, Shuang A; Shi, Yang; Jain, Bharat R; Bertelsen, Sarah E; Kapoor, Manav; Marcora, Edoardo; Sikora, Elizabeth; Andrews, Elizabeth J; Martini, Alessandra C; Karch, Celeste M; Head, Elizabeth; Holtzman, David M; Zhang, Bin; Wang, Minghui; Maxfield, Frederick R; Poon, Wayne W; Goate, Alison M.

Cell ; 185(13): 2213-2233.e25, 2022 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-35750033

19.

TREM2 drives microglia response to amyloid-ß via SYK-dependent and -independent pathways.

Wang, Shoutang; Sudan, Raki; Peng, Vincent; Zhou, Yingyue; Du, Siling; Yuede, Carla M; Lei, Tingting; Hou, Jinchao; Cai, Zhangying; Cella, Marina; Nguyen, Khai; Poliani, Pietro L; Beatty, Wandy L; Chen, Yun; Cao, Siyan; Lin, Kent; Rodrigues, Cecilia; Ellebedy, Ali H; Gilfillan, Susan; Brown, Gordon D; Holtzman, David M; Brioschi, Simone; Colonna, Marco.

Cell ; 185(22): 4153-4169.e19, 2022 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-36306735

20.

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.

Tracy, Tara E; Madero-Pérez, Jesus; Swaney, Danielle L; Chang, Timothy S; Moritz, Michelle; Konrad, Csaba; Ward, Michael E; Stevenson, Erica; Hüttenhain, Ruth; Kauwe, Grant; Mercedes, Maria; Sweetland-Martin, Lauren; Chen, Xu; Mok, Sue-Ann; Wong, Man Ying; Telpoukhovskaia, Maria; Min, Sang-Won; Wang, Chao; Sohn, Peter Dongmin; Martin, Jordie; Zhou, Yungui; Luo, Wenjie; Trojanowski, John Q; Lee, Virginia M Y; Gong, Shiaoching; Manfredi, Giovanni; Coppola, Giovanni; Krogan, Nevan J; Geschwind, Daniel H; Gan, Li.

Cell ; 185(4): 712-728.e14, 2022 02 17.

Artigo em Inglês | MEDLINE | ID: mdl-35063084

BVS IEC

Instituto Evandro Chagas

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